HLSC 3464U Lecture Notes - Lecture 10: Helicobacter Pylori, Stomach Cancer, Atrophic Gastritis
Document Summary
3rd most common cause of cancer-related death worldwide. H pylori predisposes individuals to gastric adenocarcinoma. H. pylori is a group i carcinogen. Less than sanitary conditions, increases ulcers, excessive bleeding and pain. In africa, up to 91% of their population have had h. pylori in their lifetime. Once an individual has infection, chronic inflammatory response, several decades, several mutations over the cell cycle. Increased acidic reactions, lower ph level, end up as gastric carcinoma. Stages of normal gastric mucosa into gastric carcinoma. In particular salt has been a catalyst to gastric cancer, favorable to tumor microenvironment. Requires iron to thrive, implicated that red meat with high iron levels facilitate this response, increase gastric cancer. Most people don"t know they have this infection in the early stages. Individuals more likely to have h. pylori dietary salt, red meat, geographic location. Most common malignancy in the us/canada but is so often inaccurately reported.
