PHAR 100 Lecture Notes - Lecture 24: Xeroderma Pigmentosum, Percivall Pott, Hiv

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Nikki Philbrook

Document Summary

Describe the major causes of cancer and cancer death in men and women. Explain current ideas of how chemicals cause cancer. Discuss the aims, principles, and goals of cancer chemotherapy. 1775: percival pott (london surgeon) described scrotum cancer in young chimney sweeps which he attributed to chronic soot exposure and they called it soot-wart. 1910: clunet in france demonstrated expose of rats to x-rays caused cancer. Others showed that x-rays could cause cancer in humans in 1914. 1915: yamagiwa and ichikawa (japanese) produced skin cancer by putting coal tar on rabbit ears. 1930: kennaway and co-workers isolated polycyclic hydrocarbons from coal tar through fluorescence. 1938: hueper showed that 2-naphthylamine caused bladder cancer when given to dogs. 1961: liver cancer was a large issue in england and caused death in young turkeys, ducks, and chickens. The cause was peanut meal as poultry feed and the peanuts had a fungus (aspergilus flavus) on them which produced aflatoxin (carcinogen)