ANP 1107 Lecture Notes - Lecture 5: Hairy Cell Leukemia, Hematopoietic Stem Cell Transplantation, Infectious Mononucleosis

• School: University of Ottawa
• Department: Anatomy and Physiology
• Course: ANP 1107
• Professor: Jackie Carnegie

Document Summary

Introduction to the immune system chapter 17: p 640-645, 21: 764-789. 3. 1 list 5 different types of leucocytes & brief description of structure & function: Only formed elements that are complete cells; <1% total blood volume; 4000-11,000 wbcs/ l of blood; less than rbc; protection against bacteria, viruses, parasites, toxins, tumor cells. Diapedesis: can leave bloodstream to mount immune or inflammatory response. Endothelial cell (inflam site) signal wbc; once out of bloodstream; leukocyte move through tissue space by amoeboid motion (flowing cytoplasmic extensions). Positive chemotaxis: follow chemical trail of molecules released by damaged cell/leukocyte to id tissue damage/infection area. Leukocytosis: count>11,000/ l; (cid:271)od(cid:455)"s respo(cid:374)se to (cid:271)a(cid:272)terial or viral invasion; double in hrs. 2 categories on structural & chemical characteristics; granulocyte (obvious membrane-bound cytoplasmic granules) & agranulocyte (lack obvious granules) Most abundant-least wbc; never let monkeys eat bananas; neutrophil, lymphocyte, monocyte, eosinophil, basophil: granulocytes (neutrophils, basophils, eosinophils); all phagocytes.