PHAR 100 Lecture Notes - Lecture 8: Hyperlipidemia, Atheroma, Dyslipidemia
13 Jul 2016
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Document Summary
Accumulation of fatty plaques (atheroma) on the inside wall of arteries. Due to hyperlipidemia- elevated lipid concentration in the blood. Cholesterol ( c : made in the body and consumed in foods o. Triglycerides (tg: most abundant in the body, glycerol + 3 fatty acids o. Exogenous (through the diet) and endogenous (made in the body) Circulated through the body by proteins known as apolipoproteins (apoproteins) Intermediate o (bad lipoproteins: derived from idl o. Carry cholesterol to tissues including arteries: main cause of atherosclerosis. (hyperlipidemia, dyslipidemia): excess lipids in the blood. Secondary: acquired, associated with other metabolic diseases. Resins (+ charge) binds to bile acids (- charge) Lead to prevention of reabsorption from the intestine. Leads to lower levels of cholesterol and ldl. Inhibits production of vldl in the liver, o o. Precursor to making cholesterol in the liver (reductase) Makes mevaolnate acid (precursor) which is converted into cholesterol. Bind to hmg and prevent it from converting into cholesterol.
