BCH 4123 Lecture Notes - Lecture 17: Hypocalcaemia, Secondary Hyperparathyroidism, Fluoride Therapy
20 Mar 2017
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Document Summary
Increased osteoclast activity and osteoblastic activity: no net loss in bone, primary pthism, hyperthyroidism, paget"s disease, uncoupled. Increased resorption: multiple myeloma (specific defect in osteoblast maturation, solid malignant tumors (especially in severely ill patients, elderly. Increased formation: osteoblastic metastasis (prostate and breast cancers, fluoride therapy, rickets in children and osteomalacia in adults, causes, usually lack of vit d or calcium. Investigations: xray and bone density scan, lab, decreased serum ca and po4, highly increased alp (osteoblast marker, decreased 25-oh or 1,25-oh vit d, widened osteoid seams. 1,25oh vit d, magnesium (magnesium needed for casr) ph: trousseau"s sign of hypocalcemia, ph decreases and muscle goes into spasm, chvostek"s sign of hypocalcemia, tapping nerve on face and causes grin, diagnosis, post thyroidectomy hypoparathyroidism. Stomach: converts food into milky liquid of partially digested food, body of stomach is where secretion occurs. Duodenum: digestion of lipids, pancreatic lipase, phospholipase, digestion of starch, pancreatic amylase, digestion of sugars.
