BIO 1140 Lecture Notes - Lecture 14: Guanylyl Cyclase, Sh2 Domain, Growth Factor
14 Mar 2018
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Document Summary
Ras keeps activated and cell grows uncontrollable (how cancer starts) One of the triggers was the absence of growth factor signaling. Propose how growth factor signaling via receptor enzymes can act to prevent apoptosis. Make sure the cell has plenty of anti-apoptosis to prevent the cell from going to apoptosis. Intracellular catalytic domain acts as an enzyme. Initiates a cascade of phosphorylation-dephosphorylation than amplifies the ligand"s impact on target cell. When binds and change conformation, activates catalytic domain. Involved in pathways linked to survival, growth, proliferation and metabolism. Signaling is initiated via an area called an sh2 domain (src homology) Main second messengers: ras and derived from phospholipids. Bind with ligand bind with another ligand. Now can activate catalytic domain and phosphorylate. Intracellular signalling molecule that the cell releases. Function: inside the cell to carry out the cascade. Sends message and amplifies it from ligand. Sh2 and sh3 domains are conserved regions that bind to the p-tyr.
