BPS 3101 Lecture Notes - Lecture 1: Rna Splicing, Euchromatin, Pax6
4 Oct 2016
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Study of collective genomes in an environmental community. Heritable effects if na methylation, histone midification. Study of how human genetic makeup influences drug response. Feb. 2001 draft sequence (some gaps & seq ambiguities) Oct. 2004 finished euchromatic sequence: not including heterochromatin where there are very few genes. In bp (base pairs) 3. 2 x 109 bp or 3. 2 billion bp. There is about 20 000 25 000 genes (coding proteins) In somatic cells (diploid) 46 chromosomes: 2 copies of 22 autosomes and 2 sex chromosomes. In gametes (egg, sperm) 23 chromosomes: 1 copy of 22 autosomes and 1 sex chromosome. The nuclear genome is divided into 24 linear chromosomes. Eukaryotic (but not prokaryotic) genes usually contain introns. Bacterial genes are often organized in operons with short intergenic. Polycistronic mrna, but each gene has its own start and stop codons o. Neighboring operons might be in opposite orientation in genome: genes encoded on another dna strand o.
