HSS 2342 Lecture Notes - Lecture 32: Vitamin B12 Deficiency, Atrophic Gastritis, Nasal Spray

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 2342
• Professor: Keir J Menzies

Document Summary

Lecture 11 chapter 10 nutrients for energy metabolism. Closely related to folate: methyl from folate reactivates vitamin b12 (see fig. Shared functions with folate: regeneration of methionine, synthesis of dna and rna. Independent functions: maintains sheath on nerve cells, bone cell activity and metabolism. Absorption is complex, requires: hydrochloric acid, pepsin, intrinsic factor (if, site: terminal ileum. Deficiencies: reflects poor absorption, not intake, rare. Lack of if and/or hcl (happens in atrophic gastritis in old adults: can occur in vegan diets, the anemia is similar to that see(cid:374) (cid:449)ith folate large, i(cid:373)(cid:373)ature (cid:272)ells. This e(cid:454)plai(cid:374)s (cid:449)h(cid:455) taki(cid:374)g e(cid:454)tra folate can get rid of the anemia due to vitamin b12 deficiency, but not the neurological symptoms caused by (cid:448)ita(cid:373)i(cid:374) b(cid:1005)(cid:1006) defi(cid:272)ie(cid:374)(cid:272)(cid:455). Should(cid:374)"t supple(cid:373)e(cid:374)t folate (cid:271)e(cid:455)o(cid:374)d (cid:1005)(cid:1004)(cid:1004)(cid:1004)(cid:373)g/da(cid:455) as a result - it masks b12 deficiency. Food sources: almost exclusively in animal products, bioavailability greatest in milk and fish. Can be injected or provided as a nasal spray.