PHA 3112 Lecture Notes - Lecture 8: Pleomorphic Undifferentiated Sarcoma, Hepatocellular Carcinoma, Glioblastoma Multiforme
12 Mar 2018
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Cancer = proliferative disease (classified on basis of tissue from which it developed) Common adenocarcinomas (largest group: secretory epithelia, lung, colon, breast, pancreas, stomach, esophagus, prostate, endometrium, ovary. Common squamous cell carcinomas: protective cell layers, skin, nasal cavity, oropharynx, larynx, lung, esophagus, cervix. Other carcinomas: small-cell lung carcinoma, large-cell lung carcinoma, hepatocellular carcinoma (liver), renal cell carcinoma, transitional-cell carcinoma (of urinary bladder) Epithelial cells: >90% of cancers (80% of cancer related deaths) Largest portion of cancer: largest mortality (because of number affected not because of deadliness) A sarcoma is a cancer that arises from transformed cells of mesenchymal origin. Liposarcoma, leiomyosarcoma (smooth muscle cancer), rhabdomyosarcoma (skeletal muscle cancer), malignant fibrous histiocytoma, synovial sarcoma, angiosarcoma, chondrosarcoma. 1% of all tumors rare but deadly group of cancers) Leukemia: malignant progressive disease in which the bone marrow and other blood- forming organs produce increased numbers of immature or abnormal leukocytes (suppress the production of normal blood cells, leading to anemia and other symptoms)
