PHS 4300 Lecture Notes - Lecture 8: Coronary Artery Bypass Surgery, Venous Thrombosis, Deep Vein Thrombosis

• School: University of Ottawa
• Department: Physiology
• Course: PHS 4300
• Professor: Frank Feiner

Document Summary

Any drop in o2 supply is called hypoxia: anemia can cause this. Reduced blood flow in the veins leads to venous engorgement: edema, reduced removal of co2 and wastes. Reduced flow of lymph: causes excess plasma/fluid to diffuse into interstitial spaces, blockage of lymph flow leads to lymphedema. Thrombus: stationary blood clot in a vessel, made of platelets, clotting factors, and fibrin, causes: Dehydration, heart failure, shock, aging, trauma, surgery, sedentary lifestyle, and smoking: causes claudication (pain from moving, venous thrombi can be asymptomatic but also at risk for pulmonary embolism. Embolus: a broken piece of thrombus that travels and lodges in a distal artery, results in complete blockage (occlusion) If thrombus from left side of the heart, may travel to the brain and cause ischemic stroke. If venous thrombus, may travel to lungs and cause pulmonary embolism: prevention with anricolagulants, other causes of embolism. Fat, tumor metastasis, bacterial clumbs, air, amniotic fluid.