BIOB50H3 Lecture Notes - Lecture 10: Rhodopsin, Glycosylphosphatidylinositol, Cytosol
Document Summary
Lecture 10 synth of secreted proteins, membrane proteins, lipid-anchored proteins, glycol, membrane lipids. Proteins are sorted to the er by transmembrane transport, just like they are mitochondria, chloro, and peroxisome. They can be further sorted by vesicular transport to other compartments or cell surface. Have er signal sequence at n-terminal generally. Include: soluble proteins, transmembrane proteins, or those destined. Hydrophobic amino acids at n-terminus, the first thing synthesized by for golgi, secretion, lysos mrna + ribosomes. Er signal sequence emerges first the ribosome. The ribosome is then directed to the er membrane, for a co-translational process. Protein is sorted during translation is the definition of that and the protein is unfolded during the translation process. Signal recognition particle (srp) and srp receptor have gtpase domains (they bind gtp) Ribosome ---> protein translocator channel (translocon), a gated channel. Ribosome forms a tight seal with the translocator. This prevents the diffusion of ions, small molecules.