BIOD35H3 Lecture Notes - Lecture 4: Lactate Threshold, Lactate Dehydrogenase, Acetyl-Coa

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Anaerobic non-oxidative energy pathways work all the time (in the presence and absence of oxygen) Glycolysis occurs in the cytosol, as does substrate-level phosphorylation. Etc and krebs cycle occurs in the mitochondrion. Two different types of glucose uptake: insulin-stimulated glucose uptake. When glucose in the blood is detected by the pancreas, which releases insulin. This stimulates glut-4 to move to the cell membrane and imbed. This requires insulin for it to happen: contraction mediated glucose uptake. Contraction stimulates glut-4 to move to the cell membrane. When muscle contracts, it increases the amp/atp ratio, which breaks down atp. This actives ampk (amp activated protein kinase) This causes glut-4 to move and imbed in the cell membrane, allowing glucose to enter the cell: this is how glucose enters the cell. Pdh cannot convert pyruvate to acetyl-coa fast enough. This causes a back-up, which is why it pyruvate gets shuttle to lactic acid.

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