EESA10H3 Lecture Notes - Lecture 4: Biomonitoring, Diethylstilbestrol, Miscarriage
28 Jan 2017
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Data mostly from animal studies, not much from human exposure. Have a similar structure and properties as some of the hormones. Our body can mistakenly absorb some of these chemicals (they are not hormones). Disrupt the function of the hormones: direct effects: bind to hormone receptors alter the appearance of some genes changes in the level of produced proteins, indirect effects: altering hormone production altering hormone transport altering hormone metabolism. Des (diethylstilbestrol: synthetic estrogen used by physicians to prevent spontaneous abortion (1948-1971, administered for early pregnancy until 35 weeks, > 1million women took it between 1960-1970, daughters whose mothers took des have increased incidents of : Health implications: feminization of males, abnormal sexual behavior, birth defects, altered time to puberty, cancer of mammary glands or testes, thyroid dysfunction pituitary gland. Neurobehavioral effects: prenatal and early postnatal exposures, pcbs: polychlorinated Thyroid produces hormones (tsht1 . t2) that are regulated by hormones from the.
