EESA10H3 Lecture Notes - Lecture 4: Endocrine Disruptor, Miscarriage, Bisphenol A
20 Mar 2019
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Document Summary
Chemical hazards and human health: endocrine disrupters. Neurobehavioral implications: chemical body burdens, organochlorine substances. Produce hormones which regulate very important functions. Endocrine disrupters disrupt normal function of hormones by mimicking them. Toxicology data mostly from animal studies, not much from human exposure: direct effects: Changes in the level of produced proteins: indirect effects: Fetus more sensitive than adults: synthetic estrogen used by physicians to prevent spontaneous abortion (1948-1971, administered for early pregnancy until 35 weeks, > 1million women took it between 1960-1970, daughters whose mothers took des have increased incidents of: Endocrine disrupters health implications: feminization of males, abnormal sexual behavior, birth defects, altered time to puberty, cancer of mammary glands or testes, thyroid dysfunction, thyroid gland produces t3 and t4, pituitary gland produces tsh (thyroid stimulating hormone) Endocrine disrupters neurobehavioral implications: prenatal and early postnatal exposures, pcbs (polychlorinated biphenyls): Those who live in the foothills clearly did a better job.
