PSYD35H3 Lecture Notes - Lecture 8: Opioid Receptor, Partial Agonist, Chemoreceptor Trigger Zone
Document Summary
There are multiple different opioid receptors opiate drugs don"t need to act on all of them to work. Those with extremely long carbon chains can fold up to fit into the receptor. Pain: highly unpleasant sensory and emotional experience associated with actual or potential tissue damage. Chronic pain: serves no useful purpose, causes suffering, limits adls, and increases the costs of health care and disability; lasts more than 3 months there are two types: nociceptive pain: caused by tissue damage. Processes that increase or decrease nociception are pro/anti-nociceptive (analgesic: neuropathic pain: caused by a lesion or some dysfunction of the nervous system. Potential solution: block pain receptors during surgery. Pain signaling: pain signals arise from the periphery. Perception of pain is ultimately experienced: descending pathway: inhibitory and excitatory pathways spinal cord modulating the. Drugs may provide pain relief by: reducing the firing of the nociceptive neurons at the periphery (site of injury)
