BIO130H1 Lecture Notes - Lecture 14: Basal Lamina, Connexon, Connexin
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BIO130H1 Full Course Notes
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Document Summary
Blue nuclei; green proteins; red protein expressed in cells that prevent leaching. Cells need to be continually renewed; stem cells in red crypts replace damaged epithelial cells. Example of all proteins that are needed to be expressed and communicated with each other. Cells connected in junctions that allow cytoskeleton to be connected to the cytoskeleton of another cell; giving shape to an overall structure, not just one. Basal laminate created and secreted into epithelial cells, linking cytoskeleton to the cell, attaching to the basal lamina. Underneath is some connective tissue as there are fewer cells, tend not to be connected to each other, but connected through extracellular matrix. Cytoskeletal filaments provide resistance to mechanical stress. Anchorin, occluding, channel-forming junctions all present in epithelial sheets. Junctions arranged in a specific order, important for functions. Top occluding junctions seals gap between epithelial cells to disallow things from getting in easily. Occluding junctions that create a tight seal between cells.
