BIO130H1 Lecture Notes - Lecture 13: Hydrolysis, Coiled Coil, Centrosome
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Shrinking: if gtp is lost, then tubule begins to fall apart, filaments curl and come off: curl because non-covalent bonds that join dimers together are stronger than that of lateral proto-filaments. When gtp cap is lost, curling action (bond between lateral filaments (left and right) are lost first, then bonds within filaments (above and below) maintained) This feature is called dynamic instability where plus ends are stabilized by gtp cap, but if gtp cap is lost then depolymerisation occurs, allowing them to be dynamic) In cells microtubules are nucleated at the mtoc. Minus ends stabilized by microtubule organizing centre, plus ends are on the outside with gtp cap to stabilize them. Ce(cid:374)troso(cid:373)e : nucleates the formation of microtubules, the minus end is stable, the plus end is dynamic and may grow and shrink. Nerve cells in your spinal cord extend to your finger tips! Vesicles transported down microtubules down axons to fingertips. Acts as highways in the cell to transport.
