BIO130H1 Lecture Notes - Lecture 4: Chris Paul, Endoplasmic Reticulum, Nomen Dubium
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BIO130H1 Full Course Notes
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Lecture 4: genomes & chromosomes: genome: e(cid:374)tirety of a(cid:374) orga(cid:374)is(cid:373)"s hereditary i(cid:374)for(cid:373)atio(cid:374, over 35 different mammals have been sequenced. Neanderthal genome sequence: approximately 65 % of sequence obtained, dna recovery from bones from a 38 000 year old site in croatia, modern humans with non-african ancestral genomes contain approximately 1-4 % neanderthal dna. Partial sequence analysis shows only 78 amino acid variants in protein coding genes that might impact function. 3 billion base pairs per genome: one maternal + one paternal genome = you. ~ 25 000 genes spread across 23 chromosomes. Comparing genome sizes: advances in automated sequencing have made possible the sequencing of many genomes. Prokaryotic genomes in hours, eukaryotic gnomes in days. Single celled eukaryote: has 670 billion base pairs, human genome has 3 billion, an organisms complexity and size are not reflected in genome size. The human genome: only 1. 5 % of your genome encodes protein. Lines long interspersed nuclear element (greater than 500 base pairs)
