BIO130H1 Lecture Notes - Lecture 4: Opioid Peptide, Amine, Proline
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BIO130H1 Full Course Notes
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Bio130 lecture 4 introduction to protein structure. Carboxyl group on one amino acid is reacting with amino group on second amino acid, releasing molecule of water: creates very strong peptide bond. This is leu-enkephalin, a pentapeptide of tyr-gly-gly-phe-leu: it is a natural opioid peptide which down modulates the perception of pain. The pentapeptide leu-phe-gly-gly-tyr has no pharmacological effects: the nh2-cooh orientation of the peptide is essential for function. 3. 6 residues: about 3. 6 amino acids per turn, really important structure that almost all proteins can form since hydrogen bonding needed takes place along the polypeptide backbone, not the r-groups needed. How is it different from dna double helix: protein is single stranded. Peptide backbone in helix and the r-groups are sticking out (the variable part: dna is the opposite, with the bases in and the backbone out. Think of as two antiparallel lines of students holding hands: 2-10 strands.
