BIO130H1 Lecture Notes - Lecture 21: Basal Lamina, Laminin, Proteoglycan
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BIO130H1 Full Course Notes
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Check p. 331, figure 9. 9 and the figure legend. There is slight staggering of the microtubules meaning there is some offset. Chapter 7: interactions between cells and their environment. In between is the basement membrane, known as the basal lamina. Specialized ecm were some cells are attached from epithelial. Sometimes it is included in the epithelial tissue in diagrams. Cells are attached to each other (some are attached to basal lamina) Not a static structure - it is remodeled over time. Secreted by fibroblasts, epithelial and smooth muscle cells. Generally, these cables are composed of three chains wound around in a triple helix. Gag - highly neg charged and will attract sodium and sugar. All proteoglycan are lipoproteins (reverse is not true) One of the sugars on the disaccharide is an amino sugar (n-containing) This gag is spun directly from the cell surface by a membrane protein complex. Long chain of repeating disaccharide subunits (up to 25k)
