BIO230H1 Lecture Notes - Lecture 11: Tumor Suppressor Gene, Macrophage, Caspase 8
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BIO230H1 Full Course Notes
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Half of all cancers are mutations in p53. Which the cell duplicates and segregates its genome. G(cid:1005), a(cid:374)d g(cid:1006) are part of i(cid:374)terphase. M phase is(cid:374)"t just (cid:373)itosis, its nullear division and cytoplasmic division. Pink is the cell cycle checkpoints, yellow are the decisions it makes, green is what the cell asks. Theres no start poi(cid:374)t, (cid:271)ut (cid:271)(cid:455) traditio(cid:374) the e(cid:374)d of g(cid:1005) is the start (cid:272)he(cid:272)kpoi(cid:374)t. if it does(cid:374)"t start, it stops a(cid:374)d (cid:449)aits, the (cid:272)ell does(cid:374)"t ha(cid:448)e to kill itself, it just stops. These are the (cid:1007) (cid:373)ajor checkpoints, some cells may have more checkpoints. If the(cid:455) are (cid:449)orki(cid:374)g, it allo(cid:449)s it to pass. If its (cid:374)ot (cid:449)orki(cid:374)g, it does(cid:374)"t let it pass. To (cid:373)ake it a(cid:272)ti(cid:448)e, it (cid:374)eeds to be phosphor(cid:455)lated. It uses atp to phosphor(cid:455)late a target, it does(cid:374)"t tra(cid:374)sfer its phosphate o(cid:448)er, it uses atp to phosphorylate something. At the end of (cid:373)itosis, (cid:449)e do(cid:374)"t (cid:374)eed to phosphor(cid:455)late thi(cid:374)s a(cid:374)(cid:455)(cid:373)ore so (cid:449)e destro(cid:455) thr m-cdk.
