BIO130H1 Lecture Notes - Lecture 3: Signal Peptidase, Nuclear Pore, Transmembrane Protein
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BIO130H1 Full Course Notes
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The proteins are placed into a vesicle and move to the golgi. The golgi glycosylates the protein or modifies it. The proteins then is placed in another vesicle. The vesicle now fuses with the plasma membrane. Can be regulated or constitutive: constitutive = non stop excretion; if you have it, excrete it, regulated pathway = proteins are stored until a stimulus is sensed leading to excretion. The plasma membrane eats and a vesicle is formed. The vesicle travels to lysosome for digestion. Pulse chase experiment: fire a pulse of radioactive amino acids, chase that pulse with non-radioactive amino acids, follow that path to see where the proteins go. Post translational sorting: a protein is made in the cytosol, the protein is then sorted to the mitochondria or chloroplast, the proteins tend to be unfolded until they reach the correct place. Co-translational process: while protein is being made, head of the protein is already being inserted into the er.
