HMB300H1 Lecture 3: Lecture 3- Plastic(ity) Surgeons.pdf
Document Summary
Ca2+ and camkii lead the way. Nmda receptors permits the entry of calcium. Camkii- must be involved in ltp strengthening process. This increases its kinase activity overall. Alters ltp as well as learning. Strengthening of synapse does not occur as well, neither does learning. T286 to cause an increase in activity) Camkii is important for ltp as well as for learning assays. Movement of camkii into activated spines. Camkii seems to be the molecule involved in ltp need. Camkii to move into spines in order to activate them. Structural plasticity as a result of camkii moving into the spine. It will split into 2 synapses. Camkii: during ltp (strengthening of synapses), we may go back and form larger spine heads, ltd: lose of spines. Ampar: get a bigger response because there are more ampar binding to glutamate that is being released. All receptors that bind glutamate = inotropic. Ligand gated ion channels (ampar/nmdar) binds glutamate to enable ion flow.
