IMM250H1 Lecture Notes - Lecture 1: Cowpox, Smallpox, Variolation
Document Summary
4 categories of pathogens innate immunity adaptive immunity. Secondary encounter with a pathogen faster response and higher magnitude. Smallpox scab from person with mild symptoms inserted under the skin. Smallpox declared dead: no animal reservoir, contagious only at symptomatic stage, disease of world wide concern, effective and easy delivery of vaccine (bifurcated needle, sufficient funding. Injected puss from cow pox into a kid kid developed mild symptoms. When exposed to smallpox by variolation, he didn"t get symptoms. Antitoxins are receptors that lock and key bind toxins. Binding of toxins causes more antitoxins to form and be released. Immunity can be transferred by wbc without serum. Immune system gradually acquires the ability to distinguish the bodies tissue from foreign tissue. Each lymphocyte makes one kind of antibody (not many ehlrich) Exposure of mice in utero to cells of a different strain makes them tolerant to skin grafts of that strain later on.
