IMM250H1 Lecture Notes - Lecture 3: Adaptive Immune System, Innate Immune System, Microorganism
Document Summary
First line of defense (needed to activate the adaptive immune system) Without it: infections are controlled at first but they are not cleared. Mamps to recognize microbes outside of cells and. Damps (danger signals released by the bodies dead or dying cells) Recognize conserved chemical structures of microbes not found in host cells. Lots of pg in their cell wall (pamp) Also have lipotheichoic acid and teichoic acid (pamp) Thin layer of pg in between outer and inner membrane. Acid fast staining: red (non-acid fast stain blue) Alum, silica, asbestos: soluble prr/prm: (in blood and tissues) Enhance phagocytosis by leukocytes through opsonisation (coating microbe with prr opsonin: cell-signalling prrs: (leukocytes and other cells) Rig-i-like receptors: intracellular receptor: lbp binds lps in blood and brings it to the plasma membrane, cd14 binds lps and moves close to tlr4 and. Signal transduction to nfkb (and irf) cytokine (and interferon) production. Nfkb is in the cytoplasm and guarded by ikb.
