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IMM250H1 Lecture : Notes taken during lecture

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redtermite204
15 Feb 2011
School
UTSG
Department
Immunology
Course
IMM250H1
Professor
J.Gommerman

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Document Summary

Midterm approximately 2 hours, all multiple choice questions. results will be posted before drop date. march 1st material not covered on midterm. Adaptive immunity requires recognition of antigen; takes longer to develop, days to weeks; can recognize 10 billion antigen specificities due to random rearrangement process in bone marrow at dvj locus. highly variable immune system can recognize just about anything and everything. Two major subsets of lymphocytes b and t: b secrete antibodies which have same specificity as b cell receptor displayed on surface of b cell, t lymphocytes expand and become effector t cells. Debate whether humoral or cellular immunity is more important. Cellular response t cell response helped by dendritic cells. Na ve recipient someone who has never seen the infection before. ex. response to tb cannot transfer tb immunity with only serum.

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Related Questions

Distinguish innate and adaptive immunity, including the cells and receptors involved in each response, the timing of each response and the types of antigens recognized. How is adaptive immunity dependent on the innate response? What specific cells link the two responses to pathogens?

  1. What common cytokines induce differentiation of TH1 and TH2subsets?

  2. Put the number of the correct description from Column B beforeeach term in Column. Use each term only once.

    Column A Column B

    ___ cytokines
    ___ Tc cell
    ___ pathogen
    ___ active immunity
    ___ MHC molecule
    ___ epitope
    ___ passive immunity
    ___ plasma cells
    ___ Th cell
    ___ adjuvant

    1. generates an immune response after vaccination
    2. the direct transfer of a specific antibody into a host
    3. B cell that secretes an antibody
    4. displays CD8 glycoproteins on its surface
    5. organism that causes a disease
    6. presents antigens to TCR can recognize it
    7. displays CD4 glycoproteins on its surface
    8. immunologically active region of an antigen
    9. enhances the immunogenicity of antigens
    10 molecules that signal cells to perform functions
  3. Explain why burn victims are at extreme risk for infection.Which type of immunity is compromised in these patients? (3marks)
  4. What are the three types of cells capable of phagocytosis? Howare microbes recognized by phagocytic cells?
  5. What do reactive oxygen species (ROS) and reactive nitrogenspecies (RNS) do to microbial cells? List one reactive oxygenspecies that phagocytic cells produce .
  6. Where are Toll-like receptors (TLRs) located? What TLR wouldrecognize a bacterium that possesses a flagellum? What result doesTLR-bacterium binding produce and how would that trigger an innateimmune response?
  7. What is the acute phase response (APR)? What are the maincytokines and a few of the proteins are involved in it? What doesthis response contribute to innate immunity?
  8. What is septic shock? Describe the role of LPS in causingsepsis.
  1. What common cytokines induce differentiation of TH1 and TH2subsets?
  2. Put the number of the correct description from Column B beforeeach term in Column. Use each term only once.
  3. Column A Column B

    ___ cytokines
    ___ Tc cell
    ___ pathogen
    ___ active immunity
    ___ MHC molecule
    ___ epitope
    ___ passive immunity
    ___ plasma cells
    ___ Th cell
    ___ adjuvant

    1. generates an immune response after vaccination
    2. the direct transfer of a specific antibody into a host
    3. B cell that secretes an antibody
    4. displays CD8 glycoproteins on its surface
    5. organism that causes a disease
    6. presents antigens to TCR can recognize it
    7. displays CD4 glycoproteins on its surface
    8. immunologically active region of an antigen
    9. enhances the immunogenicity of antigens
    10 molecules that signal cells to perform functions
  4. Explain why burn victims are at extreme risk for infection.Which type of immunity is compromised in these patients?
  5. What are the three types of cells capable of phagocytosis? Howare microbes recognized by phagocytic cells?
  6. What do reactive oxygen species (ROS) and reactive nitrogenspecies (RNS) do to microbial cells? List one reactive oxygenspecies that phagocytic cells produce
  7. Where are Toll-like receptors (TLRs) located? What TLR wouldrecognize a bacterium that possesses a flagellum? What result doesTLR-bacterium binding produce and how would that trigger an innateimmune response?
  8. What is the acute phase response (APR)? What are the maincytokines and a few of the proteins are involved in it? What doesthis response contribute to innate immunity?
  9. What is septic shock? Describe the role of LPS in causingsepsis.