IMM250H1 Lecture Notes - Lecture 1: Antimicrobial Peptides, Candida Albicans, Tight Junction
Document Summary
Plan a: physical constitutive barriers (mechanical, chemical, biological factors), work to block invasion. Plan b: innate response (humoral components, i. e. complement, coagulation, cytokines cellular components such as neutrophils, monocytes/macrophages, nk cells, eosinophils, epithelial cells) In conjunction, may induce adaptive immunity (b and t cell responses, antibody responses) Skin, mucosa, constact contact with the external environment inhibit free entry of microbes to internal tissues mucosa are more vulnerable to microbial invasion (e. g. respiratory, urinary, g. i. tract are all mucosal) Three basic types of barrier defense mechanical, chemical, biological they require no induction (exist prior to pathoogen exposure) Epithelial and mucosal surfaces provide these types of barrier defense pathogens cannot enter the host to replicate unless they pass these barriers. Lysozymes in tear ducts cilia and ora in nasal/throat passages more mucus and cilia lining the trachea stomach acidity inhibits microbial growth ora in gut. Skin, epithelium physical barriers with tight junctions.
