IMM350H1 Lecture Notes - Lecture 1: L-Selectin, Ccl21, Icam-1
Document Summary
Selectin: l-selectin (cd62l) -- binds to glycam-1 and cd34. Lymph -> blood at thoracic duct (point of lowest pressure) T cells not activated by apc exit ln via cortical sinuses. T cells activated proliferate and lose ability to exit ln -> activated differentiate into effector that can leave. Rolling (selectins) -> activation (chemokines) -> adhesion (integrins) -> diapedesis (chemokines) Lymphocyte enters hev in lymph node -> l-selectin binds to glycam- 1 and cd34 (rolling) -> lfa-1 activated by ccr7 in response to. Ccl21 -> lfa-1 binds to icam-1 -> lymphocyte migrates into lymph node by diapedesis. Selectins: low affinity interactions slow down t cells: l-selectin (cd62l): lectin-like domain that binds specific carbohydrate. Integrins: provide high affinity interactions: all t cells: lfa-1 ( (cid:1006) + l(cid:895) (cid:271)i(cid:374)ds to. Icam-1 on hev or apc: subset of na ve t cells: lpam-1 ( 7.
