IMM250H1 Lecture : Lecture notes

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redtermite204

2 Feb 2012

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C3b can be associate with c4b2a in this configuration, this is now comlex that has capaicity to activate compleement component five, or c5. When activated by alternative pathway, c3bbb form c3b2bb- also c5 convertase, One of the functions of complement is to facilitate the opsonization of pathogens by macrophages. Very constant theme throughout the complement pathway . C3a, c5a, c4a, - c5a is most effective interact with cells of endothelial and cause local inflammatory responses. Lysis of target pathogen lysis is complex series of events ivolving set of proteint hat result in lysis of targets. C5 is cleaved by c5 convertases by soluble product c5b functions to initate mebrane attack complex, mac, consequence of recruitment of series of proetins, c6, which binds to c5b, and this forms acceptor for c7. C7 is recruited amphilphilic coplex has both hydrophilic and hydrophobic portions and can peentrate into lipid bilayers . Wide variety of proteins that can regulate complement pathway c1 inhibitor c1.

Related Questions

1. Macrophages express multiple types of receptors on their surface that stimulate phagocytosis of microbes, leading to pathogen internalization and destruction. Many of these receptors, such as Dectin-1, rely on direct recognition of a PAMP on the pathogen surface. However, some receptors that stimulate phagocytosis rely on soluble factors (not associated with the phagocyte membrane) to identify and mark the pathogen for uptake by the phagocyte. One such receptor is:

		a) The class A scavenger receptor
		b) The complement receptor
		c) The mannose receptor
		d) The macrophage C-type lectin receptor
		e) The lipid receptor

2. Toll-like receptor (TLR) signaling pathways lead to the activation of NFkB and of IRF family transcription factors. Each pathway has multiple steps, beginning with adapter proteins in various combinations. This process will induce inflammatory cytokine gene expression rapidly. The following are such adapter proteins EXCEPT:

a) MyD88

b) MAL

c) TRIF

d) NFkB

e)TRAM

3. Many of the inflammatory mediators produced by tissue macrophages at sites of infection act on the endothelial cells lining the blood vessel walls. An exception to this is (are) the:

		a) Cytokines that induce increased vascular permeability
		b) TNF produced by tissue-resident sensor cells
		c) Bradykinin produced that causes pain
		d) Chemokines that induce directed migration of blood monocytes
		e) Cytokines that induce increased expression of adhesion molecules

apricotfish623

1. What are the Components of first line of defense?

2. What are the Components of second line of defense?

3. What are the features of five types of leukocytes?

4. What are Complements? How are complements activated?

5. What is Phagocytosis? What are the stages of phagocytosis?

6. What is opsonization and opsonin?

7. What are the major steps involved in acute Inflammation?

8. How do Interferons prevent viral infection?

Neutrophils and macrophages are both phagocytic cells. How do these cells recognize foreign cells. (include the receptors and tell me which ones are common to neutrophils and which are on macrophages).

IMM250H1 Lecture : Lecture notes

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