MGY378H1 Lecture Notes - Helper Virus, Hemolytic Anemia, Parvovirus

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redtermite204

3 Jun 2013

School

UTSG

Department

Molecular Genetics and Microbiology

Course

MGY378H1

Professor

Alan Cochrane

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Document Summary

Mgy378 dna viruses february 27, 2012. Will not discuss baculovirue; iridoviruses; but rest, excluding hepadna, will be discussed. Relative size of viruses very different . Capsid most are icosahedral; others are helical, complex. Pox virus does not resemble any other virion. Envelope or not small viruses are naked, no envelope. Single stranded or double stranded all genomes are double stranded except for parvoviruses of viruses to be discussed. Papova is old nomenclature papilopma and polyomaviruses initially grouped together into one family because close resemblance similar size, characteristics, etc but some fundamental differences. Only pox virus brings in its own rna polymerase life cycle in cytoplasm others live in nucleus. Other viruses wil have exposure to dna polymerase, Pox does not have that exposure need to have extra luggage . Correlation some between size of virion and size of genome. Large group of viruses widespread in variety of animals. Two big subfamily one infects vertebrates, other infects insects.

Related Questions

2.)

a.) Are viruses that infect Archaea different from other bacterial viruses?

Yes, they do not have protein coats because of the extreme conditions where they live.

No, they consist of nucleic acid and protein just like other bacterial viruses.

Yes, the structure of archaeal viruses is always completely different from other bacterial viruses.

Yes, they have only DNA genomes.

b.) Of the following examples, which is not a common part of many viral life cycles?

The pox virus genome is replicated by DNA polymerase.

Adenoviruses attach to the cell and the nucleocapsid is taken up by the cell.

Pox viruses replicate in the cytoplasm of the cell.

Once an adenovirus virion is inside a cell, host RNA polymerases transcribe early genes

c.) Some viruses are associated with cancer. There are a variety of ways in which viruses may affect a cell in a way that may lead to cancer. Based on your knowledge of the life cycles of viruses and of molecular genetics, what is one way that this might happen?

Viral genetic material inserts into a host genome close to the termination sequence, far downstream of the promoter, and causes a silent mutation.

Viral genetic material inserts into a host genome in a repetitive noncoding region.

Viral genetic material inserts into a host genome, placing a promoter in a new location and turning on a gene that had previously been turned off.

Viral genetic material inserts into a host genome and causes a mutation in a promoter, turning off a gene that had previously been turned on.

d.) Which statement describes the difference between the normal neuron protein PrP^C and the pathogenic version PrP^Sc?

PrP^C is just a protein and the PrP^Sc is a protein with nucleic acid inside.

The PrP^C protein contains more beta sheets while the PrP^Sc protein contains more alpha helices.

The three-dimensional conformation is identical, but the amino acid sequence is different.

The amino acid sequence is identical, but the three-dimensional conformation is different.

MGY378H1 Lecture Notes - Helper Virus, Hemolytic Anemia, Parvovirus

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