PCL201H1 Lecture Notes - Lecture 16: Risk Assessment, Median Toxic Dose, Therapeutic Index
11 Jan 2018
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Document Summary
Toxicology: study of harmful effects of chemicals and agents on living organisms, different: toxicities, exposures, mechanisms, hazard probability, results of adverse effects, prevention by understanding mechanism (receptor or bioactivation: can oxidize macromolecules) Toxicant: human activities: drugs, environmental contaminants, naturally occurring substances. Toxicologists: basic and clinical research, work with chemical, pharmaceutical, biotech industries, ensure safety, analyze data, industry, companies, government, etc, classi ed: purpose/application, organ affected, research area of study. Toxicity: structural analysis, in vitro, in vivo, human studies (after the fact) Exposure (acute, subacute, subchronic, chronic: timescales: study in lab vs. real life, direct sampling or indirect, biomagni cation (food cycle, persistance. Certain safety factor: csf = ld1/ed99 (want this high)
