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Worlsey (24)
Lecture 4

Lecture 4 Drug-Receptor Interaction

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Department
Pharmacology
Course
PCL201H1
Professor
Worlsey
Semester
Winter

Description
PCL 201Lecture 4Ionization is particularly important our physiological system is aqueous water is abundant and can form dipoles and dissociate to interact with particular compoundsAcidic DrugsHAHAacidic environment forced to rightweak acids will be protonatedBasesXHXHdeprotonated form more lipid soluble at low pHRule of thumb to roughly calculate percent ionization based on pKa value of drug and pH of compartmentIonization affects drug distributionAt physiological pH morphine is ionized but fentanyl is not so it can access brain more rapidly and is more potentRange of pH values in different compartmentsBlood 74 We have an effective buffer systemUrine can change more substantially 58 can be changed by diet vegetarians tend to have more basic urine High protein diets have more acidic urineSmall intestine 8Stomach 2Ionization is important for absorption and distribution reaching a particular targetCompartme
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