PSL300H1 Lecture Notes - Lecture 11: Corepressor, Protein Kinase A, Skeletal Muscle
Document Summary
Psl300 notes: endocrine part 3: hormones (lecture 11) Can be multiple receptors for one ligand or more than one ligand for one receptor. Located in cell membrane, cytoplasm or nucleus. Students often forget that the receptor can be in the cytoplasm and nucleus in addition to the cell membrane. Changes the conformation of the receptor and the activity of the receptor. Alters the activity of the intracellular pathway. Leads to changes in synthesis of target proteins (slow) Some hormones (ie: steroids) can pass right through the membrane and must have specificity with the cell. So they can have a receptor on/in the nucleus which will alter gene transcription. Or modification of existing target proteins (fast) Take a sample of androgen receptors with unlabelled testosterone bound to some of the receptors. The labelled testosterone will bind to all the receptors including the receptors that already had the previous unlabelled testosterone bound to it.
