PSL300H1 Lecture Notes - Lecture 6: Glucagon Receptor, Tyrosine Kinase, Anabolism
Document Summary
Released by beta-cells in the islet of langerhans in response to glucose, Glp1, pns: decreases blood sugar, promotes anabolic pathway and growth, released by alpha cells in response to low glucose and sns, promotes catabolic pathway to increase energy. What is the ratio of endo/exocrine hormones of the pancreas: 98% exocrine hormones for digestion, 2% endocrine, tyrosine kinase, g-coupled receptor. How does insulin increase glucose uptake in a liver cell: glut4 only in muscle and fat. In muscle cells glut4 can be brought to membrane simply through exercise: fluorescently labelled glut4. Increases glucose uptake by activating hexokinase to decrease the concentration within the cell and using glut2 transporter to import glucose. Glucagon do on liver cell: shows that something in the small intestines is responsible for insulin release. What inhibits insulin secretion: have cortisol, epinephrine and insulin present at the same time.
