PSL301H1 Lecture 18: Lecture 18- Neural Control of Breathing

• School: UTSG
• Department: Physiology
• Course: PSL301H1
• Professor: Michelle French

Document Summary

Brainstem = generator of breathing: rhythmcally activate respiratory muscles. Stimulate movement of diaphragm (for inhalation) & transverse abdominus (for exhalation) Inspiratory muscles: diaphragm muscle by phrenic nerve, upper airway muscles by hypoglossal nerve, tongue important in sleep apnea, scalenes by cervical spinal nerve. Pressure graphs of respiration: contraction of diaphragm (occurs first to generate negative pressure in the lungs, positive inspiration, transversus abdominis contraction occurs only after diaphragmic contraction ends, negative expriation, pause airway pressure = 0 [repeat] Medulla sends motoneuron signals to activate inspiratory muscles (diaphragm & intercostal muscles) prebotzinger complex: brain area generating breathing rhythm. Interacts w/ drg synchronize inspiration & expiration. Inputs: carotid bodies & peripheral areas (medullary chemoreceptors) Outputs: vgr"s prebotzinger complex neurons change ventilation according to physiological circumstances. Outputs: internal intercostal muscles (via phrenic nerve) & active expiration muscles. Definition: sudden, non-traumatic, non-drowning death of epileptic patients. Uncoordinated brain activity & spreads through subcortical areas & prebotzinger.