PSL301H1 Lecture Notes - Lecture 14: Peripheral Artery Disease, Deep Vein Thrombosis, Rheumatic Fever
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Rheumatic heart disease (caused by streptococcal bacteria) Deep vein thrombosis (blood clot at walls of vessels) and pulmonary embolism (blood clot in circulatory system) *cardiovascular disease is a leading cause of deaths ~1/3 canadians will die of cardiovascular disease and 1/5 canadians will develop heart failures. This is influenced by genetics background (family history) or everyday lifestyle (exercise, food intake) Plague (fat, cholesterol ) aggregation in arteries, can harden or narrow your vessels. Ldl-c (low density lipoprotein) more susceptible to cvd. Metabolic disorder strong influence to atherosclerosis. Smoke (can produce chemicals that cause damage to endothelial linings increase in susceptibility of lipids depositing into blood vessels) Obesity (hormones from fat deposits can activate disease causing pathways, and can cause hypertension) Plaque (mainly cholesterol) building up in the arteries. Blood clot can dislodge and circulate in the vessel thromboembolism. Ldl cholesterol accumulates underneath the endothelial cells in the arterial wall. Starts to deposit inside the vessel wall.
