Biology 2382B Lecture 13: CELLBIOLECTURE13SECTION2-3
8 Mar 2017
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Document Summary
Redundant mechanisms and checkpoints to get chromosomes to the metaphase plate. Chromosome uses tension to know when it is captured on both sides. Ndc80 proteins become phosphorylated and releases my that is bonded. Anaphase separates the sister chromatids into their respective daughter cells. Involves movement of chromosome closer to the pole. Follows the mt towards the (-) end. Band of actin causes cytokinesis at metaphase plate. Poles are pushed apart and get further away from one another. Polymerization happens at (+) end so kinesin-5 can continue pushing. Shortening of the astral mts that are anchored to the plasma membrane. Dynein found at the end of astral mts. Pulls on mts to get to the (-) end. Pulling of the poles to increase separation. Anaphase a and b work together during mitosis. Can see that bleach between kinetochore and pole is shrinking. Very little depolymerization occurs at the (-) end. Centrosome has no depolymerization at (-) end.
