Biology 1002B Lecture Notes - Lecture 8: Chromatin, S Phase, Biochemical Cascade

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Characteristics that make drosophila an attractive model system: nuclei divides over and over again but the cell does not unlike us. It is like a cascade, one set of genes turns on another set of genes etc. Mechanism of plasmid toxin/antitoxin system as a possible origin for cell death genes. In larval there are many tissues that the flies don"t need, these un needed tissues are destroyed by programmed cell death: evolution of programmed cell death, at first cells didn"t need to die. It is a protease: called the executioner protease that cleave specific essential proteins leading to a controlled but irreversible biochemical cascade causing cell shrinkage chromatin fragmentation and cell death. Ced3 is activated and chops up proteins cell commits suicide. Possible evolutionary origin of programmed cell death genes: bacterial plasmids can code for their own transfer (mobility, once transferred the host replicates ect.

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