Biology 1201A Lecture Notes - Lecture 6: Sister Chromatids, Homologous Chromosome, Synaptonemal Complex

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Pro-metaphase i connection of spindle microtubules to kinetochores of homologous chromosomes is random. Different combinations of different alleles at different genes. Outcomes: meiosis- 4 unique cells, mitosis- 2 identical cells. Prophase of meiosis: pairing of homologous chromosomes. Mitosis- occurs in somatic cells, meiosis- occurs in sex cells. Meiosis i- separates homologous chromosomes, mitosis- separates chromatids of chromosomes. Ploidy is different: meiosis has 4 haploid and mitosis has 2 diploid. Physical exchange of sequences between chromatids of homologous chromosomes. Protein complex (synaptonemal complex) forms between homologous chromosomes. Segments of non-sister chromatids cross-over (forming chiasmata) and are swapped. Results in new combinations of alleles on chromosomes. This is how we get 4 genetically unique haploid cells. Homologous chromosomes come together on top of each other, not side by side. Misaligned recombination of homologous chromosomes- could result in duplication. Translocation!- genes on the wrong or non-homologous chromosome. Prometaphase i connection of spindle microtubules to kinetochores of homologous chromosomes is random.

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