Biology 3355A/B Lecture Notes - Lecture 22: Huntingtin, Wild Type, Point Mutation
13 Dec 2016
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Document Summary
Modeling human diseases in yeast: the case of huntington"s disease. Common factor with all these diseases is aging: e. g. alzheimer"s and huntington"s are diseases that have onsets later in life. One imp component of aging process is the loss of proteostasis (protein homeostasis; ability of cell to keep protein functional, including folding properly and also get rid of nonfunctional ones) Stress induces several consequences (related to protein folding: environmental changes: fluctuation in temps affecting protein folding, mutations in genome, etc. They evolved stress sensors: stress sensors allow org to detect potential stresses and trigger either an adaptive response or non-adaptive response. Secretory proteins enter the secretory pathway via er. Er is a very imp organelle as it has very imp function (1, 2, 3) Secretory proteins are synthesized by the ribosomes and as they are being synthesized they get translocated into the lumen of the er via a channel (translocon)
