Microbiology and Immunology 2500A/B Lecture Notes - Lecture 14: Glycopeptide Antibiotic, Antimicrobial Resistance, Minimum Inhibitory Concentration
20 Feb 2017
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Disinfectants antimicrobial agents that are applied to inanimate objects (e. g. floors, tables, walls, etc. : bleach. Antiseptics antimicrobial agents that are sufficiently nontoxic to be applied to surface of living tissues (e. g. hand sanitizers: would not want to take intravenously and orally. Antibiotics antimicrobial agents produced naturally by bacteria & fungi that are exploited by humans to treat infectious diseases: sufficiently nontoxic to be used internally (injectable, pills, iv) Only a little toxic antibiotics in high concentrations can develop toxicity: generally not toxic to higher organisms like humans. Streak bacteria over surface of agar plate. Observe a zone of inhibition around the disk. Incubate bacteria overnight: antibiotics in the disk does not allow bacteria to grow around then. Noticed colonies of staphylococci couldn"t grow around a contaminating mould. Nobel prize in physiology and medicine (1945) At the time he published his discovery, it was not a massive breakthrough and people weren"t interested.
