Microbiology and Immunology 2500A/B Lecture Notes - Lecture 2: Immunodeficiency, Methicillin, Aureus

• School: Western University
• Department: Microbiology and Immunology
• Course: Microbiology and Immunology 2500A/B
• Professor: Summers/ Mc Cormick/ Dikeakos

Document Summary

Disinfectants are things you apply to nonliving things like bleach. Antiseptics: less toxic to us, but wouldn"t use it internally. The orgs have developed so much resistance to antibiotics that they"re untreatable now (scared of the post-antibiotic world) Inoculate all test tubes with bacteria, with increasing doses of antibiotic. There gets to a point where there"s a test tube where no bacteria can grow. Strips: can test multiple antibiotics on a plate; each strip has an antibiotic, and at the top there"s more concentration, and we can see the zone of inhibitions. Transpeptidases form cross links in cell wall; so if inhibited, can"t get crosslinks in cell wall so cell wall gets weak and it dies. Resistant to b-lactamases, but some bact produce a diff pbp (genetically coded by mec (methicillin resistance)) The transpeptidases form crossbridges like the one seen on the rightmost side of the img. Not a b-lactam; it"s a glycopeptide antibiotic.