Microbiology and Immunology 3100A Lecture Notes - Lecture 12: Programmed Cell Death, Building Implosion, Molecular-Weight Size Marker
Contribution of c. elegans to understanding apoptosis. Programmed cell death (apoptosis) is a key process. Active cellular process that is morphologically distinct from necrosis (where cells swell and burst) Programmed cell death = controlled implosion of the building; building collapses on itself in a controlled manner. Cell gets trigger for apoptosis to occur, chromatin compacts, and the cell starts to shrink a little bit. Then you get progressive breakdown of the nucleus forming apoptotic bodies: by encapsulating in little vesicles, apoptotic bodies don"t spread properly. All the potentially bad stuff (bad when outside) will be recognized and engulfed by phagocytic cells: suck up jello shots. Nucleus/chromatin is very condensed in apoptotic cell and it is broken up into 2 distinct areas. Start to see all these little apoptotic bodies just waiting to get engulfed. Dna is cleaved in a very repetitive manner. If you electrophoresed dna, you would see a dna ladder.