Microbiology and Immunology 3300B Lecture Notes - Lecture 4: Tlr3, Macrophage, Ccl2
20 May 2016
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In gram positive bacteria: peptidoglycan, lipitichoic acid, di/triacyl lipoproteins. Bacterial dna = unmethylated: human dna is often methylated for dna repair. Double stranded rna (most viral rna goes through a double stranded phase) We have our own profiling, but they are different enough to use as a pamp. 2 major types: toll like receptors and non toll like receptors. Toll like receptors responsible for identifying most pathogenic pamps can be found on plasma membrane or endosomes. Tir = signaling part of the toll like receptor. Works as a heterodimer with tlr1 and tlr6. Bacteria recognizing tlrs: recognition, dimerized tlr recruits myd88 and tirap, amplification, myd88 binds and activates irak1/4 b, traf6 ubiquinates tak1. Irak uniquinates and activates traf6: transcription, tab leaves tak1 complex, making tak1 active, tak1 phosphorylates ikk complex, which phosphorylated the inhibitor of. Nfkb (ikb: nfkb is no longer inhibited, meaning it translocates to the nucleus where it transcribes antibacterial genes c. i.
