Medical Sciences 4930F/G Lecture Notes - Lecture 9: Hypertension, High-Density Lipoprotein, Insulin Resistance
Document Summary
For example, age of onset, nutritional status, prevalence, and a defect or deficiency of insulin. So how do we progress from obesity, to insulin resistance, and then to type. 2 diabetes: relationship between insulin sensitivity and insulin release in health and disease, in a normal healthy individual, you will move along the curve shown in the figure. Let"s take a look at what occurs at the cellular level: whether cells use glucose or fatty acids to generate atp depends on whether an organism is in a fed or fasted state. Let"s take a look at what happens when blood glucose is high and low: when blood glucose is high, glucose is used to generate atp in most tissues. The excess is stored as glycogen in liver and muscle, and as triacylglycerols in adipose tissue: when blood glucose is low, fatty acids are used to generate atp in most tissues.