Microbiology and Immunology 2500A/B Lecture Notes - Natural Killer Cell, Viral Hepatitis, Endothelium

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Most soluble molecules have a role in both innate and adaptive immunity. Cytokines are proteins secreted by activated cells (such as activated immune cells). Cytokines are messengers, and they are how cells communicate with other cells and also to itself. They activate or suppress most cell behaviours such as proliferation, growth, maturation, and survival. Mode of action a cytokine binds to its receptor on the cell surface, which then signals/tells the cell how to behave. There are many cytokines that are used clinically to help treat diseases such as autoimmune diseases, viral diseases (hiv), and cancers. Cytokine families: there are six cytokine families, of which we will only talk about three. Chemokines, interferon (ifn) type i, and tumor necrosis factor (tnf) are cytokine families that all play a key role in innate immunity. Other cytokine families are interleukins (il), growth factors (gf), and colony stimulating factors (csf). Activated cells secrete many types of cytokines simultaneously.

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