Pathology 3240A Lecture Notes - Lecture 3: Rudolf Virchow, Genetic Disorder, Cytopathology

• School: Western University
• Department: Pathology
• Course: Pathology 3240A
• Professor: Geordie Shepherd

Document Summary

Rudolf virchow => father of cellular pathology (described the cellular basis of disease : everything is happening at the cellular level, (cid:862)e(cid:448)e(cid:396)(cid:455) (cid:272)ell (cid:272)o(cid:373)es f(cid:396)o(cid:373) a(cid:374)othe(cid:396) (cid:272)ell like it (cid:862) Cells constant adjusting to accommodate to extracellular stresses => maintain homeostaisis. Co(cid:374)sta(cid:374)tl(cid:455) e(cid:454)e(cid:396)ti(cid:374)g e(cid:374)e(cid:396)g(cid:455) to (cid:373)ai(cid:374)tai(cid:374) status (cid:395)uo (cid:894) if (cid:272)ell did(cid:374)"t a(cid:272)ti(cid:448)el(cid:455) (cid:396)espo(cid:374)d to so(cid:373)ethi(cid:374)g u ate => would die) Maintain a fairly narrow physiological range and takes energy to do that. The normal cell few spots very sensitive to injury =>cell death =>manifest as disease. (cid:272)ell (cid:272)a(cid:374) adapt, (cid:271)ut e(cid:448)e(cid:374)tuall(cid:455) goi(cid:374)g to (cid:271)(cid:396)eak do(cid:449)(cid:374) if (cid:272)ell does(cid:374)"t get (cid:271)ette(cid:396) Normal cell => increased stress or demand => can adapt and have a new homeostatic state. Ex 1 extra resistance to blood flow in the heart=> myocyte cells respond by getting bigger to inc pump=> thicker to overcome resistance = adaptation.