Pathology 3500 Lecture Notes - Lecture 11: Chemokine, Calorie, Chronic Myelogenous Leukemia

• School: Western University
• Department: Pathology
• Course: Pathology 3500
• Professor: shepherd

Document Summary

Biology of tumor growth: transformation (normal to tumor cell, growth of tumor cells, angiogenesis, tumor progression and heterogeneity, metastasis. Vascular endothelial growth factor (vegf) - makes blood vessel formation. In a normal tissue, wont have as many blood vessels: block blood vessels to kill tumor. Tumor progression and heterogeneity: over a period of time, the tumor may acquire various cell subpopulations. Subpopulation may vary (develop new properties: antigenicity. Steps include local invasion, intravasation into blood and lymph nodes, transit through the vasculature, extravasion from the vessels and formation of tumor: divided into two phases: invasion of ecm and vascular dissemination and homing of tumor cells. Locomotion: propel tumor cells through degraded basement membrane. Involves many receptors and signaling proteins that impinge on the actin cytoskeleton. Vascular disssemination and homing: when in the cirulation tumor cells are vulnerable to destruction by host immune cells.