Pathology 3500 Lecture Notes - Lecture 10: Advanced Maternal Age, Acne Vulgaris, Microcephaly
Document Summary
Introduction: congenital diseases, present at birth, can be due to genetic disorder, but do not have to be, genetic diseases, determined by genes, can be present at birth, or can manifest later in life. Inner lining of the amnion breaks free, and causes this free-floating amniotic band. Cause of congenital abnormalities: 50% of cases, etiology unknown, genetic cause 12-25, environmental 8-13, multifactorial 20-25, mother was exposed to specific agents teratogens. Infectious organisms: drugs and chemicals, maternal disorders. Ionizing radiation: mother is infected while pregnant, usually viruses. Infectious organisms: rubella, cmv, herpes, varicella zoster. Drugs and chemicals: used in the 50s to treat morning sickness, racemic mixture. Large babies (deformation: cardiac malformations, cns malformations, kidney malformations, the severity of the malformations is related to degree of control of maternal diabetes during the pregnancy, radiotherapy for treatment of cancer, atomic bomb explosions.
