Pathology 3500 Lecture Notes - Lecture 6: Cell-Mediated Immunity, Humoral Immunity, Antigen-Presenting Cell
Document Summary
Inflammation; one of the first responses of the immune system to infection; produced as a result of release of: cytokines released by infected/injured cells, ex interleukins, prostaglandins, leukotrienes, chemokines. Interferon promotes their killing activity, while prostaglandin e2 is highly suppressive of. Helper t cells: when apcs present peptide antigens on the mhc ii molecules, the cd4+ t-cell recognizes the antigen through the tcr. T-cells (cd4+: mostly bind peptide antigens derived from extracellular bacteria, mhc iii, not part of the peptide display system, class i mhc pathway. Il-2 induces the proliferation of t-cells, allowing for the expansion of an antigen-specific. Antibodies: major effector of the humoral immune response, composed light and heavy chains. Igg: opsonize microbes to target them for phagocytosis, activate complement, cross the placenta to protect the fetus. Iga: secreted within mucosa to protect against mucosal invasion. Ige: coats various parasites to target them for destruction by mast cells and eosinophils, also key component of allergic response.
